Table 3.
Comparison of experimentally determined and in silico predicted growth phenotypes
|
In vivo |
In silico |
Strain |
Substrate/phenotype |
Reference |
|---|---|---|---|---|
| C-source | ||||
| + | + | wt | Glycerol, L-arabinose, D-arabitol, D-ribose, D-xylose, L-xylitol, D-fructose, D-galactose, D-gluconate, D-glucose, D-mannitol, D-mannose, L-rhamnose, salicin, cellobiose, lactose, maltose, melibiose, trehalose, acetate, citrate, lactate, malate, pyruvate, succinate, tartrate, propanoate, alanine, asparagine, glutamate, glycine, histidine, isoleucine, leucine, lysine, methionine, proline, serine, threonine, tryptophan, valine | Hodgson 1980; Zhang et al. 1996 |
| ΔmsdA | propanoate | Zhang et al. 1996 | ||
| ΔglnA | no glutamine auxotrophy | Fink et al. 1999 | ||
| − | − | wt | Sucrose, arginine, methionine, phenylalanine | Hodgson 1980 |
| ΔmsdA | Valine | Zhang et al. 1996 | ||
| ΔhisA | trp− his− | Barona-Gomez and Hodgson 2003 | ||
| ΔmalE | Maltose | van Wezel et al. 1997 | ||
| ΔargG | arg− | Flett et al. 1987 | ||
| ΔmetF | met− | Blanco et al. 1998a | ||
| − | + | wt | Aspartate, glutamine | Hodgson 1980 |
| ΔtrpC1ΔtrpD1 | trp− | Hu et al. 1999 | ||
| N-source | ||||
| + | + | wt | Aspartate, asparagine, glutamate, glutamine, isoleucine, leucine, lysine, praline, valine | Hodgson 1980 |
| − | − | Δvdh | Valine, isoleucine, leucine | Tang and Hutchinson 1993 |
| +
|
−
|
wt
|
Methionine, phenylalanine
|
Hodgson 1980
|
-
(+) Growth; (−) no growth.
-
↵a The data are for Streptomyces lividans.
