Identification of functional transcription factor binding sites using closely related Saccharomyces species

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Figure 2.
Figure 2.

Diagram of the method used to calculate the probability of TFBS conservation. (A) A hypothetical two-base pair-long motif, which specifies either T or C in the first position andaGinthe second position. (B) A schematic of how the probability of TFBS conservation is calculated. In this case, two of the 16 possible descendents are conserved instances of the initial TFBS sequence. The probability of TFBS conservation is the cumulative probability of both evolutionary paths, conditioned on the initial sequence and the evolutionary time between them.

This Article

  1. Published in Advance April 18, 2005, doi: 10.1101/gr.3578205 Genome Res. 15: 701-709

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