Table 2.
Candidate gene analysis for chromosome 3 cholesterol QTL
|
Genea |
LODb |
Mbc |
COR1d |
COR1 P-value |
COR2e |
COR2 P-value |
|---|---|---|---|---|---|---|
| BC005709 | 6.7 | 87.5 | 0.25 | <.01* | 0.23 | 0.01* |
| AK006728 | 4.5 | 98.9 | 0.2 | 0.03* | 0.18 | 0.06 |
| AK018343 | 5.3 | 90.8 | 0.18 | 0.05* | 0.14 | 0.15 |
| 0610007D09Rik | 17.1 | 71.1 | -0.17 | 0.06 | 0.03 | 0.75 |
| 5430417P09Rik | 19.2 | 69.0 | 0.16 | 0.08 | 0.13 | 0.20 |
| AK018125 | 9.7 | 69.0 | -0.16 | 0.09 | -0.02 | 0.76 |
| AV361415 | 24.5 | 97.7 | -0.14 | 0.13 | -0.01 | 0.91 |
| NM_019410 | 11.9 | 59.2 | -0.14 | 0.14 | 0.01 | 0.92 |
| AK018323 | 13.1 | 60.7 | 0.09 | 0.29 | -0.01 | 0.84 |
| AK017836 | 5.2 | 97.2 | 0.07 | 0.46 | 0.01 | 0.86 |
| AA959924
|
4.8
|
35.0
|
-0.05
|
0.59
|
0.04
|
0.70
|
-
↵a GenBank accession number for each candidate gene.
-
↵b Peak LOD score for each gene eQTL.
-
↵c Physical location in megabases of each gene.
-
↵d Pearson's correlation coefficient for each gene versus cholesterol across F2 mice and associated P-value.
-
↵e Pearson's correlation coefficient for each gene versus cholesterol conditioned on genotype at the peak marker, D3Mit241, and the associated P-value. Significant correlations are indicated with an asterisk.
