Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression

Table 2.

Comparison of gene expression between daf-2 and control worms on day 6

Gene family
Gene name
Biological function
Mean fold increasea
P-value
Stress response
    hsp-16 genes hsp-16.48, -16.49b 31.2 5.7E-40
hsp-16.1, -16.11b,c 1.8 6.0E-03
hsp-16.2c Heat shock protein 142.3 4.2E-29
hsp-16.41 12.1 1.9E-21
    hsp-12 gene hsp-12.6c,d 65.3 1.3E-15
    tts transcript tts-1 Transcribed telomere-like sequence 21.4 8.9E-232
Protein metabolism
    Ribosomal proteins rpl-43, rpl-20, rpl-29, rpl-30, rpl-23, rpl-31, rpl-35, rpl-8, rpl-27, rpl-22, rps-11, rps-13, rps-7, rps-17, rps-0, rpa-1, Y105E8A. 16, M28.5, Y48G8AL.8a, Y41D4B.5 2.8 1.9E-03
Cellular signaling
    Transthyretin-like proteins ZK697.8, F22A3.2, ZC64.2, C40H1.5c, Y5F2A.2, Y51A2D.10 Signaling and transport 7.1 1.2E-03
    nlp genes nlp-27, nlp-28, nlp-29, nlp-31 Neuropeptide-like protein 8.2 9.2E-05
Gene family
Gene name
Biological function
Mean fold decreasea
P-value
Lipid metabolism
    Vitellogenins vit-4c Lipid transport 39.3 1.3E-12
vit-1, vit-2b,c,d 385.1 8.5E-115
vit-3, vit-5b,c,d 100.9 4.6E-32
vit-6d 122.4 2.2E-37
Stress response
    Cold shock cey-1, cey-2, cey-3 Cold-shock DNA-binding domain 15.1 4.3E-06
Structure
    Tubulin genes tbg-1, tbb-1, tbb-2, tba-2 Microtubule-based movement 30.1 4.5E-08
    Actin genes act-1, act-2, act-3, act-4, act-5d Cytoskeleton organization 26.6 5.0E-06
DNA/RNA metabolism
    Pumilio genes puf-3d, puf-5 RNA binding protein 19.6 4.4E-06
puf-10, puf-6, puf-7b 19.6 1.7E-06
    mcm genes mcm-2, mcm-3, mcm-4, mcm-5, mcm-6 Initiation of DNA replication 19.4 1.1E-03
Protein metabolism
    asp genes asp-1, asp-2, asp-6b,d, asp-3c, asp-4, asp-5 Proteolysis and peptidolysis 8.4 4.1E-02
    spp genes spp-1, ssp-10, spp-14 3.2 6.6E-02
    rpn genes rpn-2, rpn-8, rpn-9, rpn-11 Proteasome regulatory particle 8.1 2.3E-03
    eft genes eft-2, eft-3, eft-4 Translation elongation 28.2 3.2E-14
F17C11.9a, Y41E3.10 5.9 5.7E-03
    cct genes
cct-1, cct-4, cct-6
Cytosolic chaperone activity
6.3
7.2E-04

  • ↵a Fold increase or decrease calculated using tag frequencies.

  • ↵b Genes listed in the same line are closely related and cannot be distinguished by means of their SAGE tags. In these cases the tag numbers indicated are the sum of the tags for both or all genes on that line.

  • ↵c Overlap with Murphy et al. (2003).

  • ↵d Overlap with McElwee et al. (2003).

This Article

  1. Published in Advance April 18, 2005, doi: 10.1101/gr.3274805 Genome Res. 15: 603-615

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