Protein interaction mapping: A Drosophila case study

Table 4.

Distribution of known binding motlfs in interacting proteins, in the SID, and in the fly proteome


IPR ID

Domains

No. in map ORF

No. in map SID

No. in Drosophila proteome
IPR001478 PDZ 39a 28a 110
IPR000159 RA 11a 7a 21
IPR002110 ANK 27a 18a 136
IPR000308 14_3_3 3 3a 9
IPR000299 Band4.1/FERM 12a 7a 38
IPR001781 LIM 13 11a 78
IPR001487 Bromo 11a 5a 28
IPR000225 ARM 6a 4a 21
IPR003169 GYF 1 1a 2
IPR003116 Ras BD 4a 2a 7
IPR000253 FHA 7a 4a 27
IPR001849 PH 29a 10a 110
IPR001440 TPR 17 10a 114
IPR000157 TIR 2 2a 12
IPR001092 bHLH 18 9 109
IPR001715 CH 13a 5 53
IPR001452 SH3 26a 9 124
IPR008251 Chromo Shadow 1 1 6
IPR000727 t-SNARE 5 1 18
IPR000306 FYVE 6a 1 20
IPR000980 SH2 8 3 64
IPR000569 HECT 7a 1 22
IPR000953 Chromo 6a 1 22
IPR000449 UBA 6 2 50
IPR001680 WD-40 24 11 269
IPR001841 RING 27 7 175
IPR000270 PB1 1 0 4
IPR002014 VHS 4a 0 6
IPR001026 ENTH 1 0 8
IPR001660 SAM 8 1 43
IPR001960 EVH1 3 0 10
IPR000488 Death Domain 1 0 10
IPR001810 F-Box 4 1 44
IPR000313 PWWP 3 0 11
IPR000342 RGS 2 0 13
IPR001496
SOCS
3
0
19
  • Shown is a list of InterPro domains known to be involved in protein-protein interactions and their occurrence in the connected proteins (No. in map ORFs; total 1727), in the SID (No. in map SID; total 2484), and in the Drosophila proteome (No. in Drosophila proteome; total 20,532). Their distribution in the connected proteins and in the SIDs are compared with those in the Drosophila proteome.

  • a Significantly enriched (p < 0.05) from representation in the Drosophila proteome.

This Article

  1. Genome Res. 15: 376-384

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