Computational analysis of 3′-ends of ESTs shows four classes of alternative polyadenylation in human, mouse, and rat

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Figure 2.Figure 2.
Figure 2.

Comparison between the full-length mRNA alignments and the poly(A) EST alignments of Lamin A/C in (A) human, (B) mouse, and (C) rat. In all three species, poly(A) ESTs are clustered into two clusters, each corresponding to a poly(A) site. Lamin A and C isoforms are present in all three species. In human, a third isoform, Lamin Adel10, skips exon 10 of Lamin A. In mouse and rat, a third isoform, Lamin C2, has alternative initiation. GenBank gi numbers are shown for all mRNAs and ESTs.

This Article

  1. Genome Res. 15: 369-375

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