Positive selection of different exons of the RGP genes
|
Exon |
Ka/Ks |
2Δℓ |
p |
Sites under positive selection |
|---|---|---|---|---|
| (Ka/Ks)0 = 0.74798 | ||||
| 1-19 | (Ka/Ks)1 = 0.12120 | 21.47 | 2.210−5 | D77E; S305N; N834K (P > 0.7) |
| (Ka/Ks)2 = 4.21470 | ||||
| (Ka/Ks)0 = 0.05678 | S2523R; R2039G; Q2121R (0.85 > P > 0.8) | |||
| 20 | (Ka/Ks)1 = 0.16790 | 28.50 | 6.510−7 | L1950V; D2031G; K2338E; T2391S (P > 0.85) |
| (Ka/Ks)2 = 3.99336 | ||||
| (Ka/Ks)0 = 0.12345 | ||||
| p-q | (Ka/Ks)1 = 0.43336 | 7.47 | 2.410−2 | |
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(Ka/Ks)2 = 0.25333
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(Ka/Ks)0 and (Ka/Ks)1 indicate the Ka/Ks ratios associated to the background lineages, while (Ka/Ks)2 refers to Ka/Ks of the foreground branch (see Methods and Supplemental Fig. S2). The parameters indicating positive selection are represented in bold. 2Δℓ is twice the difference between log likelihood scores (ℓ) obtained under models B and M3 (k=2). The resulting values were then compared against a χ2 distribution with degrees of freedom equal to 2 (it is the difference in the number of parameters estimated in models B, five, and in M3, three). The sites under positive selection located in the RDB domains are underlined. The numbering is relative to the human RanBP2. p represents the probability associated to each prediction.
