ProbCons: Probabilistic consistency-based multiple sequence alignment

Table 6.

Significance test for differences in SABmark performance




Align-M

DIALIGN

CLUSTALW

MAFFT

T-Coffee

MUSCLE

ProbCons

ProbCons-ext
Align-M −<10−10 −<10−10 −<10−10 −<10−10 −<10−10 −<10−10 −<10−10
DIALIGN −<10−10 −<10−10 −<10−10 −<10−10 −<10−10 −<10−10 −<10−10
CLUSTALW −<10−10 −<10−10 −0.02 −0.01 −7.5 × 10−6 −<10−10 −<10−10
MAFFT −<10−10 −<10−10 +(0.083) −1.5 × 10−5 −<10−10 −<10−10 −<10−10
T-Coffee −<10−10 2.5 × 10−3 +<10−10 +<10−10 −0.052 −<10−10 −<10−10
MUSCLE −<10−10 1.2 × 10−7 +<10−10 +1.2 × 10−4 1.5 × 10−5 −<10−10 −<10−10
ProbCons −<10−10 +<10−10 +<10−10 +<10−10 +<10−10 +<10−10 +6.4 × 10−4
ProbCons-ext
−<10−10
+<10−10
+<10−10
+<10−10
+<10−10
+<10−10
+(0.31)

  • Entries show the p-value indicating the significance of a difference in performance between two alignment methods as measured using a Friedman rank test. Nonitalicized values above the diagonal were calculated using fD (SP) scores on all alignments, whereas italicized values were computed using fM scores. (+) Method on the left had lower average rank (better performance); (−) Method on the left had higher average rank (worse performance); parentheses denote (nonsignificant) p-values >0.05.

This Article

  1. Genome Res. 15: 330-340

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