A high-resolution multistrain haplotype analysis of laboratory mouse genome reveals three distinctive genetic variation patterns

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Figure 7.
Figure 7.

Resequencing results in regions of fragmented blocks. The wild-derived inbred strains are labeled in bold with the same color code as Figure 6. (A) Four segments in the segmentation blocks in Figure 2B. The distance between the segments is 124,387 bp, 481,367 bp, and 163,713 bp, respectively. (*) Markers that are polymorphic in laboratory inbred strains and wild-derived inbred strains of domesticus subspecies. (B) Five segments in the erosion blocks in Figure 2A. The distance between the segments is 1474 bp, 755 bp, 6117 bp, and 3219 bp, respectively. Only markers that are polymorphic in laboratory inbred strains and wild-derived inbred strains of domesticus subspecies are shown. (^)SNPs that have genotypes inconsistent with the dominant haplotype variation pattern. (C) Two segments in a 5-kb region of erosion blocks (locus 13 in Fig. 4). The distance between the two is 2080 bp. A strain name appended with a # indicates that additional strains from the same subspecies were not displayed because of lack of space. The haplotype of DBA/2J and A/J is likely to be of domesticus origin because it is very similar to that of Lewes (LEWES/Ei). The haplotype of the two 129 strains does not resemble any wild-derived strains in this sample.

This Article

  1. Genome Res. 15: 241-249

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