A high-resolution multistrain haplotype analysis of laboratory mouse genome reveals three distinctive genetic variation patterns

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Figure 1.
Figure 1.

Haplotype structure of a 2.4-Mb region at 82,865,855-85,256,831 on Chromosome 16. The top horizontal line uses color to label a distinct haplotype pattern. The region contains two large haplotype blocks (marked by the lines with cyan color at the top) that form a 2.4-Mb melded haplotype block because the small “disruptive” block at the middle (the top line with orange color) contains <5% of all SNPs in the region. Rectangles with different colors represent haplotypes in each strain; (magenta rectangles) allelic variations different from the C57BL/6J strain, (black rectangles) allelic variations identical to the C57BL/6J strain. SNP density (defined as the number of SNPs per 10 kb) is displayed in color at the bottom. Vertical gray lines across the strains display individual SNP positions. The x-axis labels the base-pair position in the region. Dotted vertical lines are regions that were selected for resequencing.

This Article

  1. Genome Res. 15: 241-249

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