Genome-wide regulatory complexity in yeast promoters: Separation of functionally conserved and neutral sequence

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 5.
Figure 5.

Distribution of the counts of blocks of n consecutive conserved bases between S. cerevisiae and S. bayanus as a function of n. The solid line is the distribution for simulated neutral sequence. The small n values of the simulated curve and the real curve overlap well when the simulated curve is scaled by a factor 0.732 (dashed line), suggesting that 73% of the promoter sequence evolves neutrally and 27% is under selection. The inset shows the probability that a block conserved between S. cerevisiae and S. bayanus is functional, given its length n.

This Article

  1. Genome Res. 15: 205-213

Preprint Server