Table 1.
Genes identified in large-scale gain-of-function screens in Xenopus
|
Gene name |
Gene product function |
Reference |
|---|---|---|
| Xwnt8 | Signaling molecule | Smith and Harland 1991 |
| noggin | Antagonist of signaling molecule | Smith and Harland 1992 |
| siamois | Transcription factor | Lemaire et al. 1995 |
| Xnr3 | Signaling molecule | Glinka et al. 1996; Smith et al. 1995 |
| Xnr1 | Signaling molecule | Lustig et al. 1996a |
| Mix.1 | Transcription factor | Mead et al. 1996 |
| Xombi | Transcription factor | Lustig et al. 1996b |
| Mard2 | Transcription factor | Baker and Harland 1996 |
| twin | Transcription factor | Laurent et al. 1997 |
| sizzled | Antagonist of signaling molecule | Salic et al. 1997 |
| dickkopf-1 | Antagonist of signaling molecule | Glinka et al. 1998 |
| geminin | Regulates DNA replication/transcription | Kroll et al. 1998 |
| gremlin | Antagonist of signaling molecule | Hsu et al. 1998 |
| XBF-2 | Transcription factor | Mariani and Harland 1998 |
| laloo | Signaling molecule | Weinstein et al. 1998 |
| XSox17 | Transcription factor | Zorn et al. 1999 |
| E2F | Cell cycle control | Suzuki and Hemmati-Brivanlou 2000 |
| XOs4 | Unknown | Zohn and Brivanlou 2001 |
| Xath2 | Transcription factor | Taelman et al. 2001 |
| β-catenin | Transcription factor | Domingos et al. 2001 |
| Baf57 | Chromatin remodeling | Domingos et al. 2002 |
| wise | Signaling molecule | Itasaki et al. 2003 |
| coco | Signaling molecule | Bell et al. 2003 |
| R-Spondin2 | Signaling molecule | Kazanskaya et al. 2004 |
| ectodermin
|
Antagonist of signaling molecule
|
Dupont et al. 2005
|
