Segmental duplications and gene conversion: Human luteinizing hormone/chorionic gonadotropin β gene cluster

Table 3.

Estimation of population crossing-over and gene conversion rates




A. Whole LHB/CGB region

B. Recombination hotspot
Estonians
Han
Mandenka
Estonians


All SNPs
≥10% MAFd
All SNPs
≥10% MAF
All SNPs
≥10% MAF
All SNPs
>10% MAF
Maximum PAC likelihood estimates (Li and Stephens 2003)
ρa (× 104) 4.16 4.43 2.91 2.34 17.00 8.93 43.21 35.91
Composite likelihood estimates (Frisse et al. 2001; Hudson 2001)
L = 0b ρ (× 104) 8.02 7.40 7.21 7.06 17.63 14.92 93.42 68.05
L = 30 ρ (× 104) 6.38 6.25 6.60 6.53 12.29 10.38 68.05 56.17
fc 14 12.5 6 6 13 16 3 2
L = 50 ρ (× 104) 6.36 6.21 6.55 6.53 12.29 10.32 67.36 54.63
f 9 8 4 3.5 8 10 2 1.5
L = 100 ρ (× 104) 6.41 6.23 6.55 6.49 12.12 10.17 57.96 52.83
f 4.5 4 2 2 4.5 5.5 2 1
L = 250 ρ (× 104) 6.41 6.13 6.82 6.68 12.18 10.11 35.96 34.58
f 2 0.5 0.5 2.5 2 2.5 3 2
L = 500 ρ (× 104) 6.49 6.20 6.49 6.42 11.80 10.25 16.11 17.74

f
1
1
0.5
0.5
1
1.5
6.5
4
  • a The population crossing-over rate per base pair, ρ = 4Necbp.

  • b L is the length of the gene conversion tract.

  • c f = g/c is the ratio of gene conversion to the crossing-over rate.

  • d SNPs with minor allele frequency ≥ 10%.

This Article

  1. Genome Res. 15: 1535-1546

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