Sequence features in regions of weak and strong linkage disequilibrium

Table 8.

Results of model fitting to describe decay of linkage disequilibrium


Round of selection

Feature added to model

Variance explained

Fitted model
Models for extent of linkage disequilibrium within 100-kb windows
1 Polymorphism (π) 0.140 E(zLD) = -0.38 zπ
2 GC 0.240 E(zLD) = -0.36 zπ - 0.32 zGC
3 Total repeats 0.316 E(zLD) = -0.38 zπ - 0.29 zGC + 0.28 zTotal repeats
4 Known gene codons 0.349 E(zLD) = -0.34 zπ - 0.39 zGC + 0.30 zTotal repeats + 0.24 zcodons
5 Centromere (5 Mb) 0.364 E(zLD) = -0.34 zπ - 0.39 zGC + 0.29 zTotal repeats + 0.24 zcodons + 0.27 zcentromere(5 Mb)
Models for extent of linkage disequilibrium within 500-kb windows
1 Polymorphism (π) 0.174 E(zLD) = -0.42 zπ
2 Total repeats 0.327 E(zLD) = -0.44 zπ + 0.39 zTotal repeats
3 GC 0.413 E(zLD) = -0.45 zπ + 0.35 zTotal repeats - 0.30 zGC
4 Known gene codons 0.442 E(zLD) = -0.42 zπ + 0.34 zTotal repeats - 0.45 zGC + 0.24 zcodons
5 Centromere (5 Mb) 0.462 E(zLD) = -0.41 zπ + 0.32 zTotal repeats - 0.46 zGC + 0.25 zcodons + 0.30 zcentromere(5 Mb)
Models for extent of linkage disequilibrium within 1000-kb windows
1 Polymorphism (π) 0.168 E(zLD) = -0.42 zπ
2 Total repeats 0.326 E(zLD) = -0.44 zπ + 0.40 zTotal repeats
3 GC 0.433 E(zLD) = -0.47 zπ + 0.36 zTotal repeats - 0.33 zGC
4 Known gene codons 0.457 E(zLD) = -0.44 zπ + 0.34 zTotal repeats - 0.49 zGC + 0.23 zcodons
5
Centromere (5 Mb)
0.482
E(zLD) = -0.43 zπ + 0.32 zTotal repeats - 0.50 zGC + 0.25 zcodons + 0.33 zcentromere(5 Mb)

This Article

  1. Genome Res. 15: 1519-1534

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