Table 4.
Chromosomal organization and quartiles of the genome, defined according to extent of linkage disequilibrium
|
|
Genome covered by HapMap |
Genome quartiles, defined using LD |
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chromosome organization |
Mean |
(±S.E.) |
(Low LD) Q1 |
Q2 |
Q3 |
(High LD) Q4 |
Trend |
||||
| Within 5 Mb of centromere | 555.4 | (±9.7) | 311.7 | 355.5 | 480.5 | 1074.0 | Increases with LD | ||||
| Within 10 Mb of centromere | 1227.0 | (±13.9) | 973.7 | 993.8 | 1138.3 | 1802.1 | Increases with LD | ||||
| Within 15 Mb of centromere | 1919.1 | (±16.7) | 1670.1 | 1699.7 | 1850.0 | 2456.8 | Increases with LD | ||||
| Within 5 Mb of telomere | 392.5 | (±8.2) | 861.8 | 367.9 | 232.4 | 108.1 | Decreases with LD | ||||
| Within 10 Mb of telomere | 806.7 | (±11.5) | 1721.1 | 797.5 | 487.8 | 220.4 | Decreases with LD | ||||
| Within 15 Mb of telomere | 1220.6 | (±13.9) | 2407.8 | 1247.8 | 796.3 | 430.2 | Decreases with LD | ||||
| Within 5 Mb of heterochromatin | 323.2 | (±7.5) | 180.6 | 229.2 | 282.8 | 600.2 | Increases with LD | ||||
| Within 10 Mb of heterochromatin | 760.3 | (±11.2) | 553.6 | 644.7 | 717.3 | 1125.7 | Increases with LD | ||||
| Within 15 Mb of heterochromatin | 1205.7 | (±13.8) | 1013.4 | 1167.0 | 1168.0 | 1474.3 | Increases with LD | ||||
| Large genomic duplications | 365.9 | (±6.4) | 237.3 | 283.6 | 415.1 | 527.5 | Increases with LD | ||||
| Large genomic duplications (cis) | 265.5 | (±5.5) | 153.5 | 191.4 | 307.9 | 409.1 | Increases with LD | ||||
| Large genomic duplications (trans)
|
159.8
|
(±3.9)
|
118.7
|
136.2
|
182.2
|
201.9
|
Increases with LD
|
||||
-
Proportion of bases in each category (per 10,000 bases) is presented for each genomic quartile.
