Sequence features in regions of weak and strong linkage disequilibrium

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 4.
Figure 4.

Genome-wide summary of fitted linkage disequilibrium values and identified “hotspots” for the rapid breakdown of linkage disequilibrium. (Top) The fitted disequilibrium coefficients for markers separated by 10 kb. Disequilibrium coefficients were calculated within 100-kb windows distributed throughout the genome. (Bottom) Intermarker intervals (in red), where linkage disequilibrium decays very rapidly, such that disequilibrium between spanning marker pairs is generally low (for details, see text). Evaluated intervals where disequilibrium did not appear to decay very rapidly are marked in light blue.

This Article

  1. Genome Res. 15: 1519-1534

Preprint Server