Genetically indistinguishable SNPs and their influence on inferring the location of disease-associated variants

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Figure 7.
Figure 7.

Caution with location inference. Example of SNP associations to expression levels of DDX17 in 42 CEPH individuals. LOD scores calculated for association using all SNPs including those with r2 = 1. An enlarged section of chromosome 17 is shown to highlight three giSNPs that are within 70 kb of each other. The peaks indicated by asterisks are giSNPS with MAF 5%. The chromosome 9 SNPs that are identical in the Morley samples are rs1556220 and rs2274750. The chromosome 17 giSNPs include rs1552472, rs6505172, and rs8081598 clustered together with rs10506772 on chromosome 12.

This Article

  1. Genome Res. 15: 1503-1510

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