Figure 5.
Duplicate gene families with potential gene dosage function. Gene duplicate family occurrence was mapped onto four genome-scale flux distributions (glucose, galactose, glycerol, and ethanol minimal medium) (Supplemental Table S4) to elucidate gene dosage function in metabolism. Reactions carrying >5% of the substrate uptake flux were considered for gene dosage function. Gene duplicate families in which a single member is lethal (on any of the four media) were excluded, since every gene duplicate family member involved in gene dosage must suffice for growth.
