Figure 5.
Repeat analysis of the KIR intronic regions showing the presence of ancient retroelements and Alu repeats (not to scale). Genes have been grouped according to their lineages (I, II, III, IV, V). Distinct domains are labeled as follows: signal peptide, D0, D1, and D2 for the Ig domains, stem, transmembrane domain, and cytoplasmic tail. Lineage I genes have a D0+D2 structure. Although the three Ig domains are shown for ptKIRnewII and ptKIRnewIII, it is likely that they contain a pseudoexon 3, indicated by the striped boxes, and express the 2D structure. Splice variants of mmKIR1D may be missing the D2 or TM domains, as indicated by the open boxes.
