Multiple sequence alignment of the novel ptKIRnewII and ptKIRnewIII genes (shown in bold) in the common chimpanzee. Periods (.) indicate identity with ptKIRnewII and dashes (-) indicate the absence of amino acids. Conserved cysteine residues in the immunoglobulin domains are highlighted. ITIM motifs are shown by asterisks. Although closely related to ptKIR2DL6, which is shown to include the D0 domain encoded by pseudoexon 3, it is not clear whether ptKIRnewII and ptKIRnewIII belong to the KIR2D or KIR3D families. The cDNA sequences for ptKIR2DL6 and ptKIR3DL4-6 have been included, and are available under accession numbers AF258806 (ptKIR2DL6), AY122876 (pseudoexon 3 of ptKIR2DL6), AF258800 (ptKIR3DL4), AF258801 (ptKIR3DL5), and AF258802 (ptKIR3DL6).
