Mulan phylogenetic tree (A) and sequence conservation profile (B) for the GATA3 gene locus from human, rat, mouse, chicken, frog, and three fish genomes. Each tree branch indicates the number of nucleotide substitutions from the closest node. Noncoding ECRs conserved (>70% identity; >80 bp) in at least four species (including human) are shaded and numbered ECR1–5. Coding exons are in blue, UTRs in yellow, intergenic elements in red, and intronic in pink. ECRs are depicted as dark red bars above each pairwise alignment. Repetitive elements are depicted as green boxes on the bottom axis. Alignments resulting from the reverse strand are shaded in gray, and blocks on the forward and reverse strands can be visualized in a dot-plot between the zebrafish and the human local alignment (C).
