EGPred: Prediction of Eukaryotic Genes Using Ab Initio Methods After Combining With Sequence Similarity Approaches

Table 4.

Summary of Predictions on Human Chromosome 13 Using EGPred



Genes

Exons
Programs (1*)
Multi-exon (2*)
Single-exon (3*)
Partial (4*)
Total genes predicted (5*)
Total exons predicted (6*)
Exon per gene (7*)
Total exon length (8*)
Exons predicted by ab initio approach only (9*)
Exons predicted by similarity only (10*)
Exons predicted by both approaches (11*)
Number of matches to annotated exons (12*)
Genscan (+) 1048 (45.2) 211 (9.1) 1058 (45.6) 2317 6712 2.89 1116630 bp (1.16) 5320 0 1392 1212
HMMgene (+) 1975 (57.6) 119 (3.5) 1337 (38.9) 3431 8372 2.44 1134771 bp (1.18) 7233 0 1139 939
Genscan (−) 1077 (47.3) 195 (8.6) 1007 (44.1) 2279 6831 2.99 975084 bp (1.01) 5360 0 1471 1215
HMMgene (−)
2025 (57.9)
101 (2.9)
1368 (39.2)
3494
8206
2.35
994322 bp (1.03)
7018
0
1188
1022
  • Predictions were made using similarity-based approach against RefSeq protein database and Intron database in combination with two different ab initio predictors—Genscan and HMMgene. The figure in column headers indicates the number of that column. The figure in parentheses in columns 2-4 denotes percentage of total predicted genes, and figure in parentheses in column 8 denotes percent of total analyzed nucleotide sequence of human chromosome 13. Columns 9-11 represent the number of exons that are predicted by only the ab initio approach, the similarity-based approach, and by both the approaches, respectively. The last column shows the number of predicted exons from each category that are found to match to that provided by public domain. These matches include the exact, partial, and overlapping exon matches.

  • * Column number.

This Article

  1. Genome Res. 14: 1756-1766

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