Example of a locus with multiple-edited transcripts from different tissues. (A) The position and orientation of Alu elements at the corresponding chromosomal location are shown at the top. Below the genomic location is the RefSeq mRNA, in black. Exons are wide blocks, UTRs are narrower blocks, and introns are dashed lines. Accession numbers for the transcripts shown are NM024917 for RefSeq mRNA, and (1) BX647969, (2) AL832849, (3) BC008067, (4) AK022749, (5) BC009437, (6) BC034272 for full-length cDNAs. (B) Partial alignment of the cDNAs overlapping with Alu sequences. A-to-G substituted bases are labeled with a boldface G. No other types of substitutions were present within the listed transcripts.
