Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions

Table 4.

Correlation Between the Gene Ontology, Expression Profiles, and Sequence Conservation in the PPRs


A. GO annotation

Total number of genes

Number of genes with encroached PPRs

Frequency (%)
Transcription regulator 203 79 39*
Structural molecule 125 35 28
Enzyme 871 225 26
Enzyme regulator 91 23 25
Cell adhesion molecule 56 14 25
Defence/immunity 29 7 24
Transporter 342 81 24
Signal transducer 362 78 22
Total
3324
921
28
B. Tissue
Total number of genes with tissue-specific gene expression
Number of genes with encroached PPRs
Frequency (%)
Brain/neuron 156 53 34**
Gastrointestinal 121 35 29
Immune 98 29 30
Reproductory 137 34 25
Endocrine 17 4 24
Circulatory/blood 22 5 24
Others 148 42 29
Total
3324
921
28
  • The numbers and the frequencies of the genes were shown for each of the GO (A) and iAFLP (B) categories. Statistical significance of the enrichment was *p < 0.0002 and **p < 0.05, respectively (for further details on the procedure, see Methods).

This Article

  1. Genome Res. 14: 1711-1718

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