Table 1.
Selected Genes At or Adjacent To Newly Identified CTCF Target Sites
|
Clone |
Accession # |
Gene |
Biological function |
|||
|---|---|---|---|---|---|---|
| Intronic CTCF target sites | ||||||
| 140 | AY457222 | DOCK-1 | Apoptosis, phagocytosis, integrin receptor pathway | |||
| 144 | AY457225 | Ubiquitin conjugating enzyme E2A related | Ubiquitin-dependent protein degradation | |||
| 163 | AY457233 | Protocadherin LKC precursor like | Regulation of cell proliferation | |||
| 294 | AY457286 | Putative prostate cancer suppressor | Electron transport | |||
| 411 | AY457336 | Coagulation factor II | Apoptosis, JAK-STAT cascade, caspase activation | |||
| 717 | AY457431 | Ahi1 isoform 1 | Mannosyl-oligosaccharide glucosidase | |||
| 1006 | AY457543 | Glycogen synthase kinase3 beta | Anti-apoptosis, morphogenesis | |||
| Exonic CTCF target sites | ||||||
| 284 | AY457278 | C-src tyrosine kinase | Mitotic S-specific transcription, zygotic axis determination | |||
| 906 | AY457503 | Translation initiation factor 3 subunit | Protein biosynthesis | |||
| Genes adjacent to CTCF target site | ||||||
| 6 | AY457178 | Cbp/p300-interacting transactivator | Transcription regulation | |||
| 94 | AY457205 | Fgd1 related F-actin binding protein | Transcription factor, morphogenesis, & organogenesis | |||
| 200 | Sphingomyelin phosphodiesterase | Neurogenesis | ||||
| 398 | AY457331 | Grb10 | Neuropeptide, insulin & EGF receptor, cell-cell signalling | |||
| 398 | AY457331 | Cordon-bleu | Neural tube formation | |||
| 447 | AY457350 | Vitamin D3 25-hydroxylase | Lipid metabolism, Ca2+ homeostasis, electron transport | |||
| 648 | AY457400 | Ubiquitin conjugating enzyme E2-related | Ubiquitin-dependent protein degradation, cell cycle control | |||
| 648 | AY457400 | Purinergic receptor P2Y | Cytosolic Ca2+ concentration elevator | |||
| 797 | AY457461 | Tolloid-like | Skeletal development | |||
| Neighboring genes | ||||||
| 144 | AY457225 | Sphingosine kinase 1 | Sphingolipid metabolism, cell communication | |||
| 163 | AY457233 | Synuclein beta | Anti-apoptosis, neurogenesis | |||
| 200 | Amyloid beta A4 precursor binding B1 | Intracellular signalling cascade | ||||
| 200 | Cholecystokinin B receptor | G protein signalling linked to IP3 2nd messenger | ||||
| 265 | AY457268 | FoxC1 | Segment polarity determination, morphogenesis | |||
| 284 | AY457278 | Cytochrome P450 1a2 | Cell growth & maintenance, electron transport | |||
| 293 | AY457285 | Mapre1 | Cell cycle control, cell proliferation | |||
| 322 | AY457302 | Paraneoplastic C-T-B related | Neurogenesis, tumor antigen | |||
| 447 | AY457350 | AMP-activated protein kinase gamma 3 | Spermatogenesis, stresss response | |||
| 717 | AY457431 | Myeloblastosis oncogene | Anti-apoptosis | |||
| 736 | AY457440 | Transformed mouse 3T3 cell double minute 2 | Negative control of cell proliferation, ubiquitin protein ligase | |||
| 1006
|
AY457543
|
Pregnane X receptor
|
Steroid metabolismolism, skeletal development
|
|||
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See Supplemental information for a complete list, including Celera and GenBank ID, Gene Ontology information and a summary of functional data for each clone.
