Comparative Evolutionary Genomics of Androgen-Binding Protein Genes

Table 1.

Positions of Genes in the Abpa/b/g Orthologous Genomic Region Between Scn1b and Uble1b in the Three Species Mus musculus, Rattus norvegicus, and Homo sapiens


Gene name

Start

Finish

Stranda

Pseudogeneb

Median KA/KSc

Celera comparisond
Mouse Chromosome 7e
    Scn1b 22722387 22733263 -
    Abpa1 22864062 22865250 - 1.261 Cg_a.ac1, Identical
    Abpbg1 22872730 22874741 + 0.925 Cg_bg.ac1, sense
    Abpa2 22899391 22900549 - 0.749 Cg_a.ab1, Identical
    Abpbg2 22911541 22913573 + 0.513 Cg_bg.ab2, Identical
    Abpbg12 22968351 22971550 - 0.894 Cg_bg.ab1, Missense
    Abpbg3 23059588 23060737 - ψ 1.103 Cg_bg.aa1, Identical, ψ
    Abpa3 23067244 23068432 + ψ 0.795 Cg_a.aa1, Identical, ψ
    Abpa12 23102839 23104016 + 0.888 Cg_a.ai1, Missense
    Abpbg4 23151387 23151716 - ψ 1.158 Cg_bg.ah1, Identical, ψ
    Abpa4 23157659 23158824 + ψ 1.188 Cg_a.ah1, Missense, ψ
    Abpa13 23225803 23226988 + 0.687 Cg_a.aj2, Missense
    Abpbg13 23296589 23297381 - ψ 0.855 Cg_bg.an1, Identical, ψ
    Abpbg5 23371211 23373004 - 0.867 Cg_bg.am1, Identical
    Abpa5 23379940 23381122 + 1.131 Cg_a.am1, Identical
    Abpbg6 23448140 23448924 - ψ 1.052 Cg_bg.a12, Missense, ψ
    Abpa6 23457498 23458686 + ψ 0.657 Cg_a.al1, Missense, ψ
    Abpbg7 23468193 23469980 - ψ 0.828 Cg_bg.al1, Identical, ψ
    Abpa7 23478045 23479219 + ψ 0.973 Cg_a.a12, Identical, ψ
    Abpbg8 23582205 23584143 - 0.530 Cg_bg.ak1, Missense
    Abpa8 23588659 23589846 + 0.539 Cg_a.ak1, Identical
    Abpbg9 23694727 23696519 - 1.156 Cg_bg.aj2, Missense
    Abpa9 23708810 23709989 + ψ 1.696 Cg_a.aj1, Identical, ψ
    Abpbg10 23784269 23786064 - 0.823 Cg_bg.ar2, Identical
    Abpa10 23798099 23799277 + 0.876 Cg_a.ar1, Identical
    Abpbg11 23852520 23854299 - 0.750 Cg_bg.aq1, Identical
    Abpa11 23862002 23863183 + 0.989 Cg_a.aq1, Missense
    Abpa14 23935733 23940927 + 1.122 Cg_a.aq2, Identical
    Uble1b 23981976 24009260 -
Singletons Cg_a.ag_1, ψ
Cg_a.ab_2
Cg_a.af_1, ψ
Cg_bg.ag1
Cg_bg.ae1, ψ
Cg_bg.af1, ψ
Cg_bg.aj1
Rat Chromosome 1f
    Scn1b 86240364 86250239 -
    Abpa1 86406893 86408040 - 1.075
    Abpbg1 86413577 86415531 + 0.908
    Abpbg2 86471441 86472350 - 0.778
    Abpa2 86479128 86480275 + 1.075
    Abpbg3 86615057 86616828 - ψ 0.709
    Abpa3 86624816 86625956 + 1.018
    Uble1b 86684151 86711255 -
Human Chromosome 19g
    UBA2 (Uble1b) 39611152 39652635 +
    SCGB4A1P 39759479 39760446 -
    SCGB4A2 39776303 39777308 -
    SCGB4A3P 39828407 39828797 + ψ
    SCGB4A4 39848385 39849843 -
    Abpbg1 39890294 39890500 - ψ
    Abpa1 39893447 39893862 + ψ
    Scn1b
40213542
40223192
+



  • a Positions and orientation of transcription were determined using the BLAT server at UCSC (http://genome.cse.ucsc.edu).

  • b Pseudogenes were predicted on the basis of in-frame stop codons or frame shifts, and/or missing exons.

  • c Median pairwise KA/KS values were calculated using codeml (Yang and Nielsen 2000).

  • d Comparison of genes predicted from C57BL/6J and corresponding genomic DNA from mouse strains 129X1/SvJ, DBA/2J, and A/J from the Celera Genomics subscription database. Gene predictions were compared at the nucleotide level to those of C57B16/J; missense and sense mutations were predicted by comparing translated cDNA sequences.

  • e Mouse gene coordinates correspond to NCBI build 30 (USCS February 2003 mm3).

  • f Rat gene coordinates correspond to Baylor RGSC v3.1 (UCSC June 2003 rn3).

  • g Human gene coordinates correspond to NCBI build 34 (UCSC July 2003 hg16).

This Article

  1. Genome Res. 14: 1516-1529

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