Segmental Duplications Flank the Multiple Sclerosis Locus on Chromosome 17q

Table 1.

Summary of Results for RH Markers on the Stanford Radiation Hybrid Map (Panel G3)


BAC clone

UCSC July 2003 position (bp)

RH marker

Number of clones in G3 panel

Retention rate (%)

Duplication detected/not detected
AC069007.3 chr17:44,081,749-44,286,700 RH32232 37 44.6 Dup
RH42841 20 24.1 Dup
AC003663.1 chr17:63,238,604-63,370,672 D17S1557* 17 20.5 Dup
RH42841 20 24.1 Dup
RH14914 10 12 Non-dup
RH42755 18 21.7 Dup
AC074102.2 chr17:58,210,816-58,381,497 RH37851 12 14.5 Non-dup
AC037475.9 chr17:58,899,542-59,015,469 RH110597* 11 13.3 Non-dup
AC025048.5 chr17:58,602,379-58,740,299 RH38146 12 14.5 Non-dup
RH84338 10 12 Non-dup
RH94909 33 39.8 Dupa
AC004686.1 chr17:58,373,575-58,507,051 RH9059 24 28.9 Dup
RH31407 11 13.3 Non-dup
RH14802 9 10.8 Non-dup
RH83863 10 12 Non-dup
AC005702.1 chr17:58,470,068-58,617,753 RH74575 9 10.8 Non-dup
RH9059 24 28.9 Dup
AC080038.3 chr17:61,048,819-61,267,940 RH32867 14 16.9 Dupb


RH99431
18
21.7
Dupb
  • Results of RH markers on the Stanford Radiation Hybrid map. All markers were analyzed in silico, but those indicated with * have been experimentally confirmed by PCR. An additional 27 microsatellite markers used in our fine-mapping experiment were also analyzed both in silico and by PCR on the Radiation Hybrid Panel G3, and the results were comparable to the ones shown here.

  • a Not in a duplicon, but the EST sequence maps with >90% identity to five separate locations on Chromosome 17.

  • b Not in a duplicon, but RH markers map to both Chromosomes 7 and 17.

This Article

  1. Genome Res. 14: 1483-1492

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