Segmental Duplications Flank the Multiple Sclerosis Locus on Chromosome 17q

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Figure 4
Figure 4

(A) Sequence landscapes of human Chromosome 17. (i) Density of perfect palindromic motifs of at least 6 bp within 250,000 base windows; (ii) recombination rate from the deCODE map; (iii) G+C percentage in 20,000 base windows; (iv) known genes based on SWISS-PROT, TrEMBL, mRNA, and RefSeq; (v) CpG islands; (vi) mouse synteny; (vii) distribution of major repeat types (LINE, SINE, LTR, and Simple) in 250,000 base windows. (B) Mouse Chromosome 11 landscapes. (i) Palindrome density; (ii) genes; (iii) G+C percent; (iv) CpG islands; (v) human synteny; (vi) distribution of major repeats. The physical location of the shared MS haplotype in human and its syntenic region in mouse are shown as red horizontal bars.

This Article

  1. Genome Res. 14: 1483-1492

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