Segmental Duplications Flank the Multiple Sclerosis Locus on Chromosome 17q

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 1
Figure 1

A mechanically stretched, DAPI-stained chromosome demonstrating multiple hybridization signals for BAC AC003663 (green) as an indication of duplicated sequences in multiple positions of Chromosome 17q. One of these signals is exceptionally strong (labeled with an *), suggesting that this area contains multiple target sequences for BAC AC003663. BAC AC005821 (red) is detected only as two signals, one for each sister chromatin, thus suggesting that no large duplicated sequences exist in this BAC. The centromere of Chromosome 17 is seen as a large red signal in the lower part of the figure.

This Article

  1. Genome Res. 14: 1483-1492

Preprint Server