Regional Patterns of Gene Expression in Human and Chimpanzee Brains

Table 5.

Association Between Segmental Duplications and Gene Expression Differences



Expressed genes

Differently expressed genes

Higher in humans

Higher in chimpanzees
Duplicationsa
Detected
%
Detected
%
p-valueb
Detected
%
p-value
Detected
%
p-value
90%-95% 663 3.6 7.4 3.7 0.049 51 4.1 0.043 23 3.1 0.064
95%-98% 448 2.4 59 3.0 0.024 37 3.0 0.039 22 2.9 0.063
98%-100% 483 2.6 120 6.0 <0.0001 103 8.2 <0.0001 17 2.3 0.083
All genes
18,340
100
1999
100

1250
100

747
100

  • a Grouped by the percent of sequence identity between the duplicated copies.

  • b p-values calculated using Fisher's Exact test.

This Article

  1. Genome Res. 14: 1462-1473

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