Table 3.
The Functional Signatures of Chromosomal Alterations Measured by Accessibility State
|
GO term name |
No. overlapping |
Genes in term |
Significance |
|---|---|---|---|
| Amplified with increased condensation | |||
| Cell communication | 147 | 3844 | 4.68E-09 |
| Cell growth and maintenance | 131 | 3385 | 5.11E-08 |
| Transcription factors | 46 | 926 | 2.57E-04 |
| Amplified with decreased condensation | |||
| Ribosome | 6 | 93 | 4.39E-03 |
| Molecular chaperone | 5 | 96 | 1.02E-02 |
| Copy numer lose with increased condensation | |||
| Cell growth and maintenance | 49 | 3385 | 6.64E-05 |
| Cell communication | 52 | 3844 | 2.04E-04 |
| Tumor suppressor
|
5
|
177
|
2.87E-03
|
-
The Gene Ontology term names of the functional signatures represented in the CGH data as measured by accessibility state. Also shown is the number overlapping with the term and the total genes in the term with the significance values. Significance was calculated from the overlap of the master list to the test list, and tested using a Bonferroni-corrected hypergeometric distribution test to determine a confidence value to reject the null hypothesis.
