Identifying Candidate Causal Variants Responsible for Altered Activity of the ABCB1 Multidrug Resistance Gene

Table 4.

Association of ABCB1 Variants and Drug Resistance in Epileptic Patients

Variant	Phenotype	Alleles					Χ²a	P^b	Genotypes									Χ²a	P^b	r² vs 3435C>T
		T	A	G			AT	GA	TT	GT	GG
2667G>T,A	Drug-resistant	184	8	266		0.66 ± 0.0048^c	4	4	39	102	80		0.87 ± 0.0019^c	0.21
	Drug-responsive	86	3	107			2	1	18	48	29
		G	T				GG	GT	TT
IVS 25+3050 G>T	Drug-resistant	286	284		2.108	0.147	69	148	68			2.840	0.242	0.84
	Drug-responsive	121	149				23	75	37
		C	T				CC	CT	TT
IVS 25+5231 T>C	Drug-resistant	259	291		0.766	0.381	57	145	73			1.560	0.458	0.80
	Drug-responsive	113	145				20	73	36
		C	T				CC	CT	TT
3435C>T	Drug-resistant	291	269		4.509	0.034	73	145	62			6.855	0.032	1
	Drug-responsive	120	152				20	80	36
		T	C				TT	CT	CC
IVS 26+80 T>C	Drug-resistant	285	271		3.782	0.052	70	145	63			5.629	0.060	0.98
	Drug-responsive	118	150				20	78	36

↵a,b Χ² and P-values for Pearson's Χ² test of association with one (alleles) and two (genotypes) d.f.
↵c Fisher's exact test P and s.e.

This Article

Published in Advance June 14, 2004, doi: 10.1101/gr.1965304 Genome Res. 2004. 14: 1333-1344

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