Table 1.

Summary of Genes and ESTs in and Flanking the Human Xp11.2 Escape Domain, and Comparison With Mouse Orthologs

Human gene/EST	X-inactivation status	Expression	Mouse gene/EST	X-inactivation status	Expression	CpG island human/mouse	Nucleotide similarity	Amino acid identity
HADH2	Inactivated	Ubiquitous	Hadh2	Inactivated	Ubiquitous	Yes/no	76%-92%	86%
FLJ32783	Escapes	Ubiquitous	NM_025660	Inactivated	Ubiquitous	Yes/yes	74%-90%	70%
SMC1L1	Escapes	Ubiquitous	Smc1l1	Inactivated	Ubiquitous	Yes/yes	92%	99%
XM_159437-like	ND^a	Brain/testis	XM_159437	Inactivated	Brain	No/no	77%	ND^b
KIAA0522	Escapes	Ubiquitous	Kiaa0522	Inactivated	Ubiquitous	Yes/yes	85%-92%	74%
BE883792	Escapes	Ubiquitous	BI155935	Inactivated	Ubiquitous	No/no	87%-94%	ND^b
SMCX	Escapes	Ubiquitous	Smcx	Escapes	Ubiquitous	Yes/yes	90%	94%
BQ269240	Inactivated	Ubiquitous^c	—	—	—	No/—	—	—
AJ271378	Inactivated	Ubiquitous^c	AK013346	Inactivated	Ubiquitous	No/no	78%-90%	ND^b
BF364272	Inactivated^d	Ubiquitous^c	BE687445	Inactivated	Ubiquitous	No/no	84%	ND^b
TSPX	Inactivated	Ubiquitous	Tspx	Inactivated	Ubiquitous	Yes/yes	81%-85%	70%

ND: Not determined.
↵a X-inactivation status could not be determined because of tissue-restricted expression and lack of expression in fibroblasts.
↵b Amino acid identity was not determined for small ESTs.
↵c Expressed in liver and fibroblasts; other tissues not tested.
↵d Variable, low-level escape.

Comparative Sequence and X-Inactivation Analyses of a Domain of Escape in Human Xp11.2 and the Conserved Segment in Mouse