Transcript Level Alterations Reflect Gene Dosage Effects Across Multiple Tissues in a Mouse Model of Down Syndrome

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 1
Figure 1

Boundaries of the proximal T(16;17)65Dn breakpoint were determined by FISH. Left: Schematic illustrating the synteny between HSA21 and MMU16, and the translocation chromosome MMU1716 with the genes at the boundaries of the triplicated segment. Chromosomal position of the two BACs used for the FISH analysis is indicated. Right: Metaphase spreads from T(16;17)65Dn mouse; BAC 134F19 (top) is in red and BAC 359P19 (bottom) is in green. Arrows point to the MMU1716 chromosome.

This Article

  1. Genome Res. 14: 1258-1267

Preprint Server



Current Issue

  1. January 2026, 36 (1)
  1. Current Issue
  1. Alert me to new issues of Genome Research