Nomenclature, Scaffold Location, and Exon/Intron Organization of Fugu Claudin Genes
|
S/No. |
Fugu scaffold number |
Fugu claudin number |
No. of exons in Fugu |
No. of exons in human orthologa |
Zebrafish orthologaexon structure |
|---|---|---|---|---|---|
| 1 | 2 | fu-cldn 5a | 1 | 1 | — |
| 2 | fu-cldn 33c | 1 | — | — | |
| 3 | 8 | fu-cldn 7a | 4 | 4 | zf-cldn 7/M |
| 4 | fu-cldn 3c | 1 | 1 | — | |
| 5 | fu-cldn 3d | 1 | 1 | zf-cldn c/S | |
| 6 | fu-cldn 27c | 1 | — | — | |
| 7 | fu-cldn 27d | 3 | — | — | |
| 8 | 102 | fu-cldn 28b | 1 | — | zf-cldn e/S |
| 9 | fu-cldn 28c | 1 | — | — | |
| 10 | fu-cldn 29a | 1 | — | zf-cldn d/S | |
| 11 | fu-cldn 29b | 1 | — | — | |
| 12 | fu-cldn 30c | 1 | — | — | |
| 13 | fu-cldn 30d | 1 | — | zf-cldn a/b/S | |
| 14 | 107 | fu-cldn 18 | 4 | 5 | — |
| 15 | 137 | fu-cldn 23b | 1 | — | — |
| 16 | 161 | fu-cldn 12 | 2 | 3 | zf-cldn 12/S |
| 17 | 196 | fu-cldn 7b | 4 | 4 | zf-cldn 7/M |
| 18 | 281 | fu-cldn 23a | 1 | — | — |
| 19 | 300 | fu-cldn 14a | 2 | 3 | — |
| 20 | fu-cldn 3a | 1 | 1 | zf-cldn h/S | |
| 21 | fu-cldn 3b | 1 | 1 | — | |
| 22 | fu-cldn 5c | 1 | 1 | — | |
| 23 | fu-cldn 6 | 1 | 1 | zf-cldn j/S | |
| 24 | 302 | fu-cldn 13 | 1 | — | — |
| 25 | fu-cldn 27a | 1 | — | — | |
| 26 | fu-cldn 27b | 1 | — | zf-cldn f/S | |
| 27 | fu-cldn 28a | 1 | — | zf-cldn e/S | |
| 28 | fu-cldn 30a | 1 | — | — | |
| 29 | fu-cldn 30b | 1 | — | zf-cldn a/b/S | |
| 30 | 415 | fu-cldn 20a | 1 | 1 | — |
| 31 | 457 | fu-cldn 31 | 1 | — | zf-cldn g/S |
| 32 | 552 | fu-cldn 1 | 4 | 4 | zf-cldn 19/M |
| 33 | 628 | fu-cldn 2 | 1 | 2 | — |
| 34 | 641 | fu-cldn 20b | 1 | 1 | — |
| 35 | 654 | fu-cldn 11b | 3 | 3 | zf-cldn 11/M |
| 36 | 696 | fu-cldn 32b | 1 | — | — |
| 37 | 812 | fu-cldn 15b | 5 | 5 | — |
| 38 | fu-cldn 8a | 1 | 1 | — | |
| 39 | 863 | fu-cldn 8b | 1 | 1 | — |
| 40 | fu-cldn 8c | 1 | 1 | — | |
| 41 | fu-cldn 8d | 1 | 1 | — | |
| 42 | 1289 | fu-cldn 11a | 3 | 3 | zf-cldn 11/M |
| 43 | 1321 | fu-cldn 10d | 4 | 5 | — |
| 44 | fu-cldn 10e | 3 | 5 | — | |
| 45 | 1339 | fu-cldn 10a | 4 | 5 | — |
| 46 | 2207 | fu-cldn 32a | 2 | — | zf-cldn I/S |
| 47 | 2235 | fu-cldn 5b | 1 | 1 | — |
| 48 | 2355 | fu-cldn 19 | 3 | 4 | — |
| 49 | 2558 | fu-cldn 26 | 4 | — | — |
| 50 | 2732 | fu-cldn 25 | 4 | — | zf-cldn 10/M |
| 51 | 2743 | fu-cldn 14b | 1 | 3 | — |
| 52 | fu-cldn 33b | 1 | — | — | |
| 53 | 2835 | fu-cldn 15a | 4 | 5 | — |
| 54 | 2840 | fu-cldn 10b | 4 | 5 | — |
| 55 | fu-cldn 10c | 4 | 5 | — | |
| 56
|
3054
|
fu-cldn 33a
|
1
|
—
|
—
|
-
Each of the predicted 56 Fugu claudin genes was named according to its human ortholog (see Fig. 1), with alphabetical suffixes if there was more than one Fugu ortholog. If a human ortholog could not be identified, the identity of such genes was confirmed after phylogenetic analysis, and new numbers were assigned from 25 onward. The scaffolds on which the different Fugu claudin genes are located are listed. The exon—intron structures of Fugu genes were predicted based on their homology to known claudin genes from other organisms, and, where the boundaries were not clear, the intron acceptor and donor sites and the corresponding open reading frames were determined by visual inspection. The number of exons encoding the human orthologs is provided for reference. Where data were available, zebrafish orthologs were classified into single (S) or multiple (M) exon genes (Kollmar et al. 2001).
-
↵a Where applicable/data available.
