Figure 5
A canonical structure for the MCs of T. brucei. The core region is a large repetitive palindrome produced by direct head-to-tail repeats running from both subtelomeres to a central inversion point. Subtelomeric regions contain nonrepetitive regions, at least some of which are VSG genes. Short subtelomeric repeats are capped by telomeres of equivalent size and sequence to those of the large housekeeping chromosomes. The structure of ICs is analogous, but contains larger, more complex subtelomeric regions.
