Genomic Regionality in Rates of Evolution Is Not Explained by Clustering of Genes of Comparable Expression Profile

Table 9.

Effect of Expression Breadth on Significance of Local Similarity in KA (Duplicate Genes Excluded)



Human—mouse

Mouse—rat
Breadth measurea
ρ
Pallb
Pgroupc
N
ρ
Pallb
Pgroupc
N
EST 0.047 0.0072 0.016 3115 0.023 0.10 0.069 3029
SAGE 0.041 0.032 0.044 2572 0.041 0.024 0.020 2740
Microarray
-0.037
0.90
0.92
1209
0.038
0.071
0.049
1559
  • a Breadth of expression was averaged over experiments in human and mouse for the human—mouse comparison, and was obtained from mouse only in the mouse—rat comparison.

  • b Pall is the number of equal or greater ρ in datasets obtained by randomly permuting all genes.

  • c Pgroup is the number of equal or greater ρ in datasets obtained by randomly permuting genes within classes of similar expression breadth.

This Article

  1. Genome Res. 14: 1002-1013

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