Genomic Regionality in Rates of Evolution Is Not Explained by Clustering of Genes of Comparable Expression Profile

Table 4.

Effect of Expression Breadth on Significance of Local Similarity (ρ) in K4



Human—mouse

Mouse—rat
Breadth measurea
ρ
Pallb
Pgroupc
N
ρ
Pallb
Pgroupc
N
EST 0.290 <0.0001 <0.0001 933 0.188 <0.0001 <0.0001 2544
SAGE 0.323 <0.0001 <0.0001 732 0.177 <0.0001 <0.0001 2351
Microarray
0.506
<0.0001
<0.0001
320
0.173
<0.0001
<0.0001
1317
  • a Breadth of expression was averaged over experiments in human and mouse for the human—mouse comparison, and was obtained from mouse only in the mouse—rat comparison. Only nondisparate gene pairs were included.

  • b Pall is the fraction of equal or greater ρ in datasets obtained by randomly permuting all genes.

  • c Pgroup is the fraction of equal or greater ρ in datasets obtained by randomly permuting genes within classes of similar K4.

This Article

  1. Genome Res. 14: 1002-1013

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