Genomic Regionality in Rates of Evolution Is Not Explained by Clustering of Genes of Comparable Expression Profile

Table 3.

Correlation Between Synonymous Substitution Rate (K4) and Expression Breadth
Human—mouse
Mouse—rat
Breadth measurea
 rb
 P
 N
 rb
 P
 N
All genes
    EST -0.203 <0.00001 1247 -0.063 0.00088 2759
    SAGE -0.125 0.00007 1057 -0.088 <0.00001 2579
    Microarray -0.187 0.00003 596 -0.057 0.0237 1592
GC≤0.5
    EST -0.341 <0.00001 322 -0.165 0.00011 570
    SAGE -0.242 0.00011 260 -0.202 <0.00001 565
    Microarray
-0.339
0.00002
148
-0.090
0.098
340

  • ↵a Breadth of expression was averaged over experiments in human and mouse for the human—mouse comparison, and was obtained from mouse only in the mouse—rat comparison.

  • ↵b Pearson's correlation coefficient between expression breadth and K4. Only nondisparate gene pairs were included.

This Article

  1. Genome Res. 14: 1002-1013

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