Genomic Regionality in Rates of Evolution Is Not Explained by Clustering of Genes of Comparable Expression Profile

Table 1.

Genomic Estimates of Local Similarity in Evolutionary Rates, Assayed by the Focal Average Correlation ρ
Human-mouse
Mouse-rat
ρa
 pb
 N
 ρa
 pb
 N
All genes
    KA 0.126 <0.0001 4596 0.055 0.0018 4116
    K4 0.334 <0.0001 4284 0.183 <0.0001 3909
    Formula 0.251 <0.0001 4178 0.179 <0.0001 3815
    Ki — — — 0.170 <0.0001 541
    Kindel — — — 0.191 <0.0001 541
Nondisparate genes
    KA 0.103 0.0003 1568 0.065 0.0010 3554
    K4 0.272 <0.0001 1377 0.166 <0.0001 3380
    Formula 0.189 <0.0001 1292 0.173 0.0002 3298
    Ki — — — 0.151 0.0016 469
    Kindel
—
—
—
0.160
0.0004
469

  • ↵a Focal average correlation = correlation coefficient for data pairs, each consisting of a gene's rate K and the mean of its neighbors within 1 Mb.

  • ↵b Number of equal or higher ρ values found in 10,000 randomly rearranged genomes.

This Article

  1. Genome Res. 14: 1002-1013

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