Comparison of Human Chromosome 21 Conserved Nongenic Sequences (CNGs) With the Mouse and Dog Genomes Shows That Their Selective Constraint Is Independent of Their Genic Environment

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Figure 2
Figure 2

(A) Numbers and direction of the different types of substitutions detected in the three lineages of human, mouse, and dog assuming an unrooted tree. (B,C,D) Relative rates of GC minus AT substitutions in CODs, intronic CNGs, and intergenic CNGs in human (B), mouse (C), and dog (D). Note the excess of GC to AT substitutions in human CODs.

This Article

  1. Published in Advance April 12, 2004, doi: 10.1101/gr.1934904 Genome Res. 14: 852-859

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