Table 4.
Functional Characterization of Positively Selected Genes in Mammals
|
Symbol |
Locus Link ID |
Highest dN/dSa |
dNb |
Description |
|---|---|---|---|---|
| CD86 | 942 | 21.9 | 0.46 | CD86 antigen |
| FCER1A | 2205 | 23.5 | 0.39 | Fc fragment of IgE |
| SPAM1 | 6677 | 99.9 | 0.38 | Sperm adhesion molecule 1 isoform 1 |
| TGM4 | 7047 | 79.2 | 0.35 | Transglutaminase 4 (prostate) |
| AKAP12 | 9590 | 82.9 | 0.30 | Kinase (PRKA) anchor protein |
| IAN4L1 | 55340 | 14.4 | 0.30 | Immune-associated nucleotide 4 like 1 |
| BRCA2 | 675 | 58.9 | 0.29 | Breast cancer 2 |
| CEACAM1 | 635 | 9.39 | 0.34 | Carcinoembryonic antigen-related cell adhesion |
| LAMP2 | 3920 | 10.5 | 0.24 | Lysosomal-associated membrane precursor |
| LGALS2 | 3957 | 21.8 | 0.22 | Lectin, galactoside-binding (galectin 2) |
| LGALS9 | 3965 | 26.9 | 0.20 | Galectin 9 |
| ITGAX | 3687 | 10.4 | 0.19 | Cell surface glycoprotein CD11c precursor |
| LOC222674 | NA | 42.4 | 0.17 | HLA class II histocompatibility antigen |
| COL5A3 | 50509 | 75.9 | 0.14 | Collagen, type V, α 3 preproprotein |
| ROS1 | 6098 | 30.1 | 0.12 | Proto-oncogene c-ros-1 protein precursor |
| AKR1D1 | 6718 | 41.6 | 0.12 | Steroid-5-β-reductase |
| CTSS | 1520 | 2.8 | 0.15 | Cathepsin S |
| NDUFV3 | 4731 | 9.3 | 0.44 | NADH dehydrogenase (ubiquinone) flavoprotein 3 |
| TSAP6 | 55240 | 71.8 | 0.09 | Dudulin 2; tumor suppressor pHyde |
| PLCE1 | 51196 | 12.6 | 0.08 | Pancreas-enriched phospholipase C |
| CAPN5 | 726 | 22.5 | 0.04 | Calpain 5 |
| RHCE | 6006 | 2.0 | 0.34 | Rh blood group antigen Evans |
| HF1 | 3075 | 63.7 | 0.27 | H factor 1, binds adrenomedullin |
| FMO1 | 2326 | 50.4 | 0.30 | Flavin-containing monooxygenase 1 |
| PGR | 5241 | 77.9 | 0.11 | Progesterone receptor |
| TIMELESS | 8914 | 5.3 | 0.09 | Timeless homolog |
| PCCA | 5095 | 7.91 | 0.05 | Similar to propionyl-coenzyme A carboxylase |
| SLC7A1 | 6541 | 9.5 | 0.07 | Solute carrier family 7 |
| THBD | 7056 | 6.7 | 0.21 | Thrombomodulin |
| TNTSF4 | 7292 | 6.3 | 0.42 | Tumor necrosis factor (ligand) superfamily |
| CMKLR1 | 1240 | 2.6 | 0.01 | Chemokine-like receptor 1 |
| AKT3 | 10000 | 3.6 | 0.0019 | Protein kinase B γ |
| CD4 | 920 | 3.1 | 0.38 | CD4 antigen (p55) |
| IBSP | 3381 | 9.0 | 0.19 | Similar to bone sialoprotein |
| CASP8 | 841 | 4.84 | 0.23 | Caspase 8 isoform B |
| MACF1
|
23499
|
8.82
|
NA
|
Microfilament and actin cross-linking factor
|
