Placement map integration algorithm. Placement maps resulting from incremental LOD thresholds between 8 and 15 were aligned. The framework bins for all maps were normalized to that of the LOD 15 map so that the bin sizes were identical across maps (left panel). The position of markers placed within the bins on all maps were accordingly adjusted to be proportional to the normalized bin size (middle panel). The normalized position from the map with the highest LOD threshold for each marker was added to the integrated map, with markers placing upstream of the first framework designated as a negative distance from that framework marker (middle panel, integrated). Finally, the absolute positions of the markers were determined with the first placed marker at 0 cR (right panel, final integrated).
