Figure 1
MAVID architecture overview. (A) Sequences are aligned upward along a guide tree and (B) alignments of alignments are performed at internal nodes. To align two alignments (C), maximum likelihood ancestor sequences are inferred from each of the separate alignments, and (D) the ancestor sequences are aligned with MAVID. The resulting multiple alignment (E) (corresponding to a subset of leaves of the tree) is then recorded at the internal node.
