Pash: Efficient Genome-Scale Sequence Anchoring by Positional Hashing

Table 1.

Read Anchoring Speed and Accuracy of Pash, BLAT, and BLAST


Program

Reads mapped/minute

Fraction in agreement with BLAST
Pash 235.5 99.2%
BLAT 39.6 99.8%
BLAST
0.6
N/A
  • Whole-genome shotgun sequencing reads from the chimpanzee genome-sequencing project were independently mapped onto the human genome by Pash, BLAT, and BLAST. BLAST mappings to a single unambiguous location were used as a reference for comparison. Because chimpanzees are closely related to humans, Pash was employed in a high-speed/low-sensitivity mode (see Adjustable Speed/Sensitivity Tradeoff for details).

    N/A means not applicable.

This Article

  1. Genome Res. 14: 672-678

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