Comparative Analysis of the α-Like Globin Clusters in Mouse, Rat, and Human Chromosomes Indicates a Mechanism Underlying Breaks in Conserved Synteny

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Figure 3
Figure 3

Blocks of tandem repeats (BTR) similar in sequence are found linked to the mouse α and pseudo-α clusters on mouse Chromosomes 11 and 17, respectively. (A) Pip of the mouse α-globin cluster on Chromosome 11 compared with mouse Chromosome 17 sequence with unmasked repeats. Along the top horizontal axis are shown genes and repeats in the mouse Chromosome 11. Gene exons and BTR are indicated and shown as black boxes. (B) Dot plot of mouse Chromosome 11 sequence (position 110-153 kb on the vertical axis) against mouse Chromosome 17 sequence (horizontal axis) with masked repeats. Note that 5′ to the pseudo-α gene cluster on Chromosome 17 are found two BTRs similar in sequence to the BTR that immediately follows θ2 (Hba-q2) on Chromosome 11 (two dark rectangles). The rectangles are generated by the clustering of a short diagonal for each 30-mer repeat unit of the BTRs.

This Article

  1. Genome Res. 14: 623-630

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