Dot plots of the mouse Chromosome 17 sequence against the human Chromosome 16 (A) and mouse Chromosome 11 (B) sequences. (A) Alignment with repeats masked of human and mouse sequences showing the presence of three α-like pseudogenes and of LUC7L exons 7–12 in the 33L10 sequence (diagonals in the plot). Note that the three exons of Hba-ps4 match human α1 (HBA1) and α2(HBA2), and, to a lesser extent, θ1(HBQ1); Hba-psm contains two exons more related to human α1 (HBA1) than α2 (HBA2); Hba-q3 consists of one exon only that matches, although poorly, human θ1 (HBQ1). (B) Alignment of mouse 11 and 17 sequences with repeats not masked. Note that the pseudo-α gene set on Chromosome 17 shows more extensive similarity to the 3′ set on Chromosome 11. The similarity extends from just 3′ of the 5′-θ (Hba-q1) gene through to the 3′-θ (Hba-q2) gene on Chromosome 11, with a gap where an IAP element and an LTR have inserted on Chromosome 17 in the region of similarity to the Chromosome 11 segment just upstream of Ψα2 (Hba-ps2).
