Homology relationship between human 16p13.3 and mouse Chromosomes 11 and 17. At the top is a schematic representation of the 16p13.3 telomere. The oval represents the telomeric repeats (TTAGGG)n. Genes are shown as boxes numbered as in Flint et al. (1997). Genes above the line are transcribed toward the centromere; those below the line are transcribed toward the telomere. Empty boxes identify pseudogenes. The α-globin regulatory element (HS-40) is
shown in dark gray. In the middle is the interstitial region of mouse Chromosome 11 containing the α-globin cluster. Genes are numbered in similarity to the
human genes. At the bottom is the region of mouse Chromosome 17 spanning the mouse LUC7L homolog and the Hba-ps4 pseudo-α gene. The dashed segment of mLuc7L indicates the region that has not yet been sequenced. The light gray area shows the 8-kb interval of the human 16p13.3 sequence
within which lie the centromeric synteny breakpoint and the centromeric limit of the human α-globin regulatory domain. The
symbol
indicates the direct repeats found at the synteny breakpoint. The mouse Chromosome 17 P1 clones 33L10 and 17N8 are shown.
