Table 2.
Classification of Rat-Specific Genes Whose Human Ortholog Has Been Inactivated by Mutation or is Absent
|
Process/protein |
Gene |
Rat locus |
Human ortholog |
Human locus |
|---|---|---|---|---|
| Digestion | ||||
| Chymosin | Cymp | 2q34 | Inactive | 1p13 |
| distal intestinal serine protease | Disp | 10q12 | Inactive | 16p13 |
| trypsin 10 | Try10 | 4q23 | Inactive | 7q34 |
| trypsin 15 | Try15 | 4q23 | Inactive | 7q34 |
| pancreatic elastase | Ela1 | 7q35 | Inactive | 12q13 |
| Reproduction | ||||
| fertilin-α | Adam-1a | 12q16 | Inactive | 12q24 |
| fertilin-α-b | Adam-1b | 12q16 | Absent | - |
| cyritestin | Adam-3b | 16q12 | Inactive | 16q12 |
| ADAM4 | Adam-4 | 6q24 | Inactive | 14q24 |
| ADAM4B | Adam-4b | 6q24 | Inactive | 14q24 |
| ADAM5 | Adam-5 | 16q12 | Inactive | 8p11 |
| ADAM6 | Adam-6 | 6q32 | Inactive | 14q24 |
| testases 1, 4, 5 | Adam-24, -34, -35 | 16q12 | Absent | - |
| testase 2 | Adam-25 | 16q12 | Inactive | 8p22 |
| testis serine protease 3 | Tessp3 | 8q32 | Inactive | 3p21 |
| testis serine protease 6 | Tessp6 | 8q32 | Inactive | 3p21 |
| testicular serine protease 1 | Tesp1 | 9q13 | Absent | - |
| testicular serine protease 2 | Tesp2 | 9q13 | Inactive | 2q21 |
| testicular serine protease 3 | Tesp3 | 17p14 | Inactive | 9q22 |
| placental cathepsins (10 genes) | Ctsj,m,q,q2,q21,r,1,2,6,7l | 17p14 | Absent | - |
| testins (3 genes) | Cmb22,23,24 | 17p14 | Absent | - |
| collagenase-like B | Mcolb | 8q11 | Absent | - |
| implantation serine protease 2 | Isp2 | 10q12 | Absent | - |
| implantation serine protease 2L | Isp2l | 10q12 | Inactive | 16p13 |
| Ppnx | Ppnx | Xq14 | Inactive | Yp11 |
| glandular kallikreins (10 genes) | rGk1-3,rGk7-12,K-32 | 1q21 | Absent | - |
| Host defense | ||||
| mast cell chymases (16 genes) | Mcpt1,1l1,1l2,1l3,1l4,2,3,4,4l1, 8,8l1,8l2,8l3,9,rMcpt4,Rmcp1 | 15p13 | Absent | - |
| granzymes (9 genes) | Gzmbl1, bl2, cl1, cl2, cl3, n, o, Rnkp7, 7l | 15p13 | Absent | - |
| airway trypsin-like (3 genes)
|
Hatl1-3
|
14p21
|
Inactive
|
4q13
|
-
Protease genes are grouped according to their putative participation in three main biological processes.
