
Unrooted phylogenetic tree of the C01 family of cysteine proteases. The testin subfamily of rodent-specific proteases is shown in red, and placental cathepsins, which are also rodent-specific, are shown in green. Branches corresponding to rat-specific members are shown in white; those mouse-specific, in red. Cathepsin L–like proteases, the only group containing one extra member in human, are shown in blue.











